Midwest Peptide sells research peptides exclusively to qualified researchers and laboratories for in vitro and laboratory use. Please confirm before continuing.
By proceeding you affirm the statements above are true. Products are sold for research use only (RUO), are not for human or veterinary use, not for use in diagnostic procedures, and have not been evaluated by the U.S. Food and Drug Administration. Full disclaimer.
For research purposes only. This compound is not FDA approved. All data presented is from clinical trials for educational reference.

A mitochondrial-derived peptide that modulates metabolic processes, with significant implications for exercise metabolism observed in rodent studies. Premium Research Peptide.
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For In Vitro Research Use Only — Not for Human or Veterinary Use
Intended Use: This compound is intended strictly for in vitro research applications only. It is not approved for human or animal use and may not be used in food, drugs, cosmetics, or diagnostic procedures.
⚠️ Legal Disclaimer: This product and associated information have not been evaluated by the FDA. No statement should be interpreted as a claim to diagnose, treat, cure, or prevent any condition. Use is strictly limited to qualified research professionals in certified laboratories.
Terms of Sale: By purchasing from Midwest Peptide, the buyer affirms they are a qualified researcher or institution, fully responsible for proper handling, storage, and usage in compliance with all applicable laws and regulations. All sales are final.
MOTS-c is a 16-amino-acid mitochondrial-derived peptide (MDP) encoded by mitochondrial DNA in the 12S rRNA region. In research it is studied for AMPK pathway activation, mitochondrial signaling, and metabolic regulation. Supplied strictly for Research Use Only.
MOTS-c is studied in preclinical research on AMPK signaling, skeletal muscle glucose uptake, mitochondrial biogenesis pathway research, and insulin sensitivity model systems. All cited studies are conducted in cellular or rodent systems consistent with RUO classification.
Mitochondrial-derived peptides (MDPs) are short peptides encoded within mitochondrial DNA rather than nuclear DNA. MOTS-c is one of several characterized MDPs (others include humanin, SHLP1-6) and is studied because mitochondrial DNA-encoded signaling represents a distinct biology from canonical nuclear-encoded peptide hormones.
Other research peptides in this category
Research articles and insights related to MOTS-C

MOTS-c inflammation research covering AMPK anti-inflammatory biology, macrophage polarization, NLRP3 inflammasome suppression, and tissue inflammation. For research use only.
April 24, 2026

MOTS-c cardioprotection research covering cardiac mitochondrial biology, ischemia reperfusion injury, metabolic cardiomyopathy, and heart failure models. For research use only.
April 24, 2026

MOTS-c sourcing guide covering supplier evaluation for a sixteen amino acid mitochondrial derived peptide and the Midwest Peptide research catalog. For research use only.
April 14, 2026

MOTS-c obesity research covering diet induced adiposity reduction, body composition, hepatic steatosis, and inflammatory biology in rodent metabolic models. For research use only.
April 14, 2026
Not for human consumption. This product is sold exclusively for research and educational purposes. It is not intended to diagnose, treat, cure, or prevent any disease.
All clinical trial data and research findings presented on this page are sourced from peer-reviewed journals and official publications. They are provided for educational reference only and should not be interpreted as medical advice or product claims.
By purchasing this product, you confirm that you are a qualified researcher and will use it in accordance with all applicable laws and regulations.
Every batch of MOTS-c ships with a third-party COA verifying purity by HPLC (>=99%), identity by mass spectrometry, and lyophilized mass. The batch-specific COA is published on this product page before purchase.
Lyophilized MOTS-c is stored at -20C for long-term storage and 2-8C for short-term use within 30 days. Avoid repeated freeze-thaw cycles. Store in original sealed vials, protected from light.
MOTS-c is not FDA-approved. The product supplied here is for laboratory and research use only and is not approved for diagnostic, therapeutic, or human use.