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SS-31 10mg
SKU: ss31
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A mitochondria-targeted tetrapeptide researched for cellular energy and oxidative protection.
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Third-Party Tested
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COA Available
Certificate of Analysis included
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Research Use Only
For laboratory research purposes
Product Details
Product Details
SS-31 (Elamipretide)
SS-31 is a synthetic tetrapeptide with the amino acid sequence D-Arg-2′6′-Dmt-Lys-Phe-NH₂, belonging to the Szeto-Schiller (SS) peptide class. Each vial contains 10mg of lyophilized SS-31 for research purposes only. Third-party tested with Certificate of Analysis (COA) available. Purity: >99%. COA Batches: MPSS001
Description
SS-31 (D-Arg-2′6′-Dmt-Lys-Phe-NH₂), also known as Elamipretide or MTP-131, is a mitochondria-targeted tetrapeptide that selectively concentrates in the inner mitochondrial membrane. It interacts with cardiolipin, a phospholipid essential for the structural integrity of the inner mitochondrial membrane and the function of the electron transport chain. In preclinical and in vitro models, SS-31 has been shown to stabilize cristae architecture, reduce mitochondrial reactive oxygen species (ROS), and support ATP synthesis efficiency.
Its unique alternating aromatic-cationic structure allows it to readily cross lipid bilayers without the need for an electrochemical gradient, distinguishing it from many other mitochondria-targeted compounds studied in research settings.
Specifications
- Unit Size: 10mg (lyophilized powder, single vial)
- Sequence: D-Arg-2′6′-Dmt-Lys-Phe-NH₂
- Molecular Formula: C₃₂H₄₉N₉O₅
- Molecular Weight: ~639.80 Da
- Form: Lyophilized white to off-white powder
- Storage: Store dry at −20°C. After reconstitution, store at 2°C–8°C and use within 48–72 hours. Avoid repeated freeze-thaw cycles.
Application Context
SS-31 is studied in vitro and in preclinical models for its potential effects on:
- Mitochondrial membrane stabilization via cardiolipin interaction
- Reduction of mitochondrial reactive oxygen species (ROS) and oxidative stress
- Preservation of ATP production under conditions of metabolic stress
- Cytoprotection in ischemia-reperfusion injury models
- Mitochondrial dysfunction associated with aging and metabolic disease
- Cardiac, renal, and neurodegenerative research models
Intended Use
This compound is intended strictly for in vitro laboratory research. It is not approved for human or animal use and must not be incorporated into food, drugs, cosmetics, or diagnostic products.
Legal Disclaimer
This product and associated materials have not been evaluated by the FDA. No claims are made regarding diagnosis, treatment, or prevention of disease. Use is restricted to qualified research professionals in certified laboratory settings.
Terms of Sale
By purchasing from Midwest Peptide, the buyer affirms they are a qualified researcher or institution. The purchaser accepts full responsibility for lawful handling, storage, and application of this material. All sales are final.
Frequently Asked Questions
What is SS-31?
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SS-31 (elamipretide) is a synthetic 4-amino-acid cell-permeable peptide that selectively binds cardiolipin in the inner mitochondrial membrane. In research it is studied for mitochondrial bioenergetics, cardiolipin-electron transport chain coupling, and cellular oxidative stress models. Supplied strictly for Research Use Only.
Is SS-31 the same as elamipretide?
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Yes. SS-31 and elamipretide refer to the same molecule. SS-31 was the developmental code; elamipretide is the international nonproprietary name. The molecule belongs to the Szeto-Schiller mitochondria-targeting peptide series.
How does SS-31 differ from other mitochondrial-targeting peptides?
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SS-31 specifically binds cardiolipin in the inner mitochondrial membrane, while other mitochondria-targeting molecules use different mechanisms (such as triphenylphosphonium-based delivery or direct electron-chain interaction). Cardiolipin binding is the distinguishing feature in the published research literature.
What is SS-31 used for in research?
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Learn More About SS-31
Research articles and insights related to SS-31
SS-31 Aging Research: Mitochondrial Decline Studies
SS-31 aging research review covering the mitochondrial decline framework, cristae deterioration in aged tissue, skeletal muscle and cardiac aging, brain and cognitive aging, cellular senescence, and lifespan/healthspan endpoints. For research use only.
April 28, 2026
SS-31 Cardiac Research: Ischemia-Reperfusion Studies
SS-31 cardiac research review covering ischemia-reperfusion injury biology, animal model designs, infarct size reduction endpoints, mitochondrial endpoints in cardiomyocytes, heart failure models, and doxorubicin cardiotoxicity research. For research use only.
April 28, 2026
Where to Buy SS-31 for Research: Elamipretide Sourcing Guide
SS-31 sourcing guide covering certificate of analysis requirements, mass spectrometry identity for the Szeto-Schiller tetrapeptide sequence, HPLC purity, endotoxin screening, manufacturing provenance, and how to distinguish research-grade from commercial peptide material. For research use only.
April 28, 2026
SS-31 vs MOTS-C: Mitochondrial Peptide Comparison Research
Head-to-head research comparison of SS-31 and MOTS-C mitochondrial peptides covering mechanism differences (membrane protection vs metabolic signaling), cardiac and aging research endpoints, and combination research designs. For research use only.
April 28, 2026
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Research Use Only. These products are not supplements, drugs, or intended for human or veterinary use. These products are for laboratory research purposes only. All product information available on this website is for educational purposes only. The products offered on this website are not intended to diagnose, treat, cure, or prevent any disease. Bodily introduction of any kind into humans or animals is strictly forbidden by law. This material is sold for in-vitro research purposes only.
