For research purposes only. This compound is not FDA approved. All data presented is from clinical trials for educational reference.
Research Use Only
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SS-31 10mg
A mitochondria-targeted tetrapeptide researched for cellular energy and oxidative protection.
Dosage
$59.9910MG
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Product Details
Product Details
SS-31 (Elamipretide)
SS-31 is a synthetic tetrapeptide with the amino acid sequence D-Arg-2′6′-Dmt-Lys-Phe-NH₂, belonging to the Szeto-Schiller (SS) peptide class. Each vial contains 10mg of lyophilized SS-31 for research purposes only. Third-party 7x tested with Certificate of Analysis (COA) available. Purity: >99%. COA Batches: MPSS001
Description
SS-31 (D-Arg-2′6′-Dmt-Lys-Phe-NH₂), also known as Elamipretide or MTP-131, is a mitochondria-targeted tetrapeptide that selectively concentrates in the inner mitochondrial membrane. It interacts with cardiolipin, a phospholipid essential for the structural integrity of the inner mitochondrial membrane and the function of the electron transport chain. In preclinical and in vitro models, SS-31 has been shown to stabilize cristae architecture, reduce mitochondrial reactive oxygen species (ROS), and support ATP synthesis efficiency.
Its unique alternating aromatic-cationic structure allows it to readily cross lipid bilayers without the need for an electrochemical gradient, distinguishing it from many other mitochondria-targeted compounds studied in research settings.
Specifications
- Unit Size: 10mg (lyophilized powder, single vial)
- Sequence: D-Arg-2′6′-Dmt-Lys-Phe-NH₂
- Molecular Formula: C₃₂H₄₉N₉O₅
- Molecular Weight: ~639.80 Da
- Form: Lyophilized white to off-white powder
- Storage: Store dry at −20°C. After reconstitution, store at 2°C–8°C and use within 48–72 hours. Avoid repeated freeze-thaw cycles.
Application Context
SS-31 is studied in vitro and in preclinical models for its potential effects on:
- Mitochondrial membrane stabilization via cardiolipin interaction
- Reduction of mitochondrial reactive oxygen species (ROS) and oxidative stress
- Preservation of ATP production under conditions of metabolic stress
- Cytoprotection in ischemia-reperfusion injury models
- Mitochondrial dysfunction associated with aging and metabolic disease
- Cardiac, renal, and neurodegenerative research models
Intended Use
This compound is intended strictly for in vitro laboratory research. It is not approved for human or animal use and must not be incorporated into food, drugs, cosmetics, or diagnostic products.
Legal Disclaimer
This product and associated materials have not been evaluated by the FDA. No claims are made regarding diagnosis, treatment, or prevention of disease. Use is restricted to qualified research professionals in certified laboratory settings.
Terms of Sale
By purchasing from Midwest Peptide, the buyer affirms they are a qualified researcher or institution. The purchaser accepts full responsibility for lawful handling, storage, and application of this material. All sales are final.
Frequently Asked Questions
What is SS-31?
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SS-31 (elamipretide) is a synthetic 4-amino-acid cell-permeable peptide that selectively binds cardiolipin in the inner mitochondrial membrane. In research it is studied for mitochondrial bioenergetics, cardiolipin-electron transport chain coupling, and cellular oxidative stress models. Supplied strictly for Research Use Only.
Is SS-31 the same as elamipretide?
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Yes. SS-31 and elamipretide refer to the same molecule. SS-31 was the developmental code; elamipretide is the international nonproprietary name. The molecule belongs to the Szeto-Schiller mitochondria-targeting peptide series.
How does SS-31 differ from other mitochondrial-targeting peptides?
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SS-31 specifically binds cardiolipin in the inner mitochondrial membrane, while other mitochondria-targeting molecules use different mechanisms (such as triphenylphosphonium-based delivery or direct electron-chain interaction). Cardiolipin binding is the distinguishing feature in the published research literature.
What is SS-31 used for in research?
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Learn More About SS-31
Research articles and insights related to SS-31
SS-31 vs MOTS-C: Mitochondrial Peptide Comparison Research
Head-to-head research comparison of SS-31 and MOTS-C mitochondrial peptides covering mechanism differences (membrane protection vs metabolic signaling), cardiac and aging research endpoints, and combination research designs. For research use only.
April 28, 2026
SS-31 Mechanism of Action: Cardiolipin Binding Research
SS-31 mechanism of action review covering cardiolipin binding, selective inner mitochondrial membrane targeting, cristae stabilization, supercomplex preservation, ROS reduction, and ATP synthesis bioenergetics. For research use only.
April 28, 2026
SS-31 Research: Elamipretide Mitochondrial Peptide Literature Review
A comprehensive review of SS-31 (elamipretide) research covering the cardiolipin-binding mechanism, cardiac ischemia-reperfusion literature, mitochondrial bioenergetics, kidney injury research, neurodegeneration, and aging mitochondrial decline. For research use only.
April 28, 2026
Important Research Notice
Not for human consumption. This product is sold exclusively for research and educational purposes. It is not intended to diagnose, treat, cure, or prevent any disease.
All clinical trial data and research findings presented on this page are sourced from peer-reviewed journals and official publications. They are provided for educational reference only and should not be interpreted as medical advice or product claims.
By purchasing this product, you confirm that you are a qualified researcher and will use it in accordance with all applicable laws and regulations.
