For research purposes only. This compound is not FDA approved. All data presented is from clinical trials for educational reference.
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PT-141
A synthetic cyclic peptide analog of α-MSH investigated for central melanocortin receptor (MC3R/MC4R) activity in preclinical models.
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Product Details
PT-141 (Bremelanotide)
For Research Use Only | Not for Human Consumption
Overview
PT-141, also known as Bremelanotide, is a synthetic peptide analogue of alpha-melanocyte-stimulating hormone (α-MSH). It acts as a non-selective agonist of melanocortin receptors (MCR), with particular affinity for MC1R, MC3R, MC4R, and MC5R. Unlike many compounds studied in similar contexts, PT-141 operates centrally via the nervous system rather than through the vascular system.
Molecular Profile
| Property | Details |
|---|---|
| Peptide Sequence | Ac-Nle-cyclo[Asp-His-D-Phe-Arg-Trp-Lys]-OH |
| Molecular Formula | C₅₀H₆₈N₁₄O₁₀ |
| Molecular Weight | 1025.2 g/mol |
| CAS Number | 189691-06-3 |
| Storage | Lyophilized: -20°C |
| Appearance | White to off-white lyophilized powder |
| Solubility | Soluble in water or dilute acetic acid |
Mechanism of Action
PT-141 functions as a melanocortin receptor agonist. Upon binding, it activates hypothalamic pathways associated with melanocortin signaling. Research has focused on its interaction with MC4R in particular, which has made it a subject of interest in studies examining:
- Melanocortin system signaling pathways
- Central nervous system receptor pharmacology
- Hypothalamic neuroendocrine regulation
Areas of Research Interest
- Melanocortin receptor pharmacology — studying MC3R and MC4R binding affinity and downstream signaling
- Neuroendocrine research — examining central pathway activation related to the melanocortin system
- Inflammatory response studies — preliminary research has explored potential anti-inflammatory properties via melanocortin pathways
- Receptor selectivity profiling — comparing binding characteristics across MCR subtypes
Purity & Quality
- Purity: ≥99% (HPLC verified)
- Peptide content confirmed via Mass Spectrometry
- Certificate of Analysis (CoA) available upon request
Disclaimer
This product is intended for research use only and is not approved for human consumption, therapeutic use, or veterinary application. It is sold strictly for in vitro and laboratory research purposes. This product is not a drug, supplement, or food additive. Researchers must comply with all applicable local, state, and federal regulations governing the use of research peptides.
Frequently Asked Questions
What is PT-141?
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PT-141 (bremelanotide) is a synthetic 7-amino-acid cyclic peptide that selectively activates melanocortin-4 (MC4R) and melanocortin-1 (MC1R) receptors. It is structurally related to MT-2 but with different receptor selectivity. In research it is studied for central nervous system melanocortin signaling. Supplied strictly for Research Use Only.
Is PT-141 the same as bremelanotide?
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Yes. PT-141 and bremelanotide refer to the same molecule. PT-141 was the developmental code; bremelanotide is the international nonproprietary name. Both names map to the identical sequence.
How is PT-141 different from MT-2?
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PT-141 is more selective for MC4R while MT-2 activates a broader range of melanocortin receptors. Research models distinguish the two molecules by the central nervous system pathways activated by MC4R versus the peripheral MC1R-mediated pigmentation pathways.
What is PT-141 used for in research?
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Important Research Notice
Not for human consumption. This product is sold exclusively for research and educational purposes. It is not intended to diagnose, treat, cure, or prevent any disease.
All clinical trial data and research findings presented on this page are sourced from peer-reviewed journals and official publications. They are provided for educational reference only and should not be interpreted as medical advice or product claims.
By purchasing this product, you confirm that you are a qualified researcher and will use it in accordance with all applicable laws and regulations.
