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PT-141
A 7-amino acid cyclic peptide analog of alpha-MSH that activates melanocortin receptors MC3R and MC4R, FDA-approved for hypoactive sexual desire disorder and studied for sexual function in clinical research. Premium Research Peptide.
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Product Details
PT-141 (Bremelanotide)
For Research Use Only | Not for Human Consumption
Overview
PT-141, also known as Bremelanotide, is a synthetic peptide analogue of alpha-melanocyte-stimulating hormone (α-MSH). It acts as a non-selective agonist of melanocortin receptors (MCR), with particular affinity for MC1R, MC3R, MC4R, and MC5R. Unlike many compounds studied in similar contexts, PT-141 operates centrally via the nervous system rather than through the vascular system.
Molecular Profile
| Property | Details |
|---|---|
| Peptide Sequence | Ac-Nle-cyclo[Asp-His-D-Phe-Arg-Trp-Lys]-OH |
| Molecular Formula | C₅₀H₆₈N₁₄O₁₀ |
| Molecular Weight | 1025.2 g/mol |
| CAS Number | 189691-06-3 |
| Storage | Lyophilized: -20°C |
| Appearance | White to off-white lyophilized powder |
| Solubility | Soluble in water or dilute acetic acid |
Mechanism of Action
PT-141 functions as a melanocortin receptor agonist. Upon binding, it activates hypothalamic pathways associated with melanocortin signaling. Research has focused on its interaction with MC4R in particular, which has made it a subject of interest in studies examining:
- Melanocortin system signaling pathways
- Central nervous system receptor pharmacology
- Hypothalamic neuroendocrine regulation
Areas of Research Interest
- Melanocortin receptor pharmacology — studying MC3R and MC4R binding affinity and downstream signaling
- Neuroendocrine research — examining central pathway activation related to the melanocortin system
- Inflammatory response studies — preliminary research has explored potential anti-inflammatory properties via melanocortin pathways
- Receptor selectivity profiling — comparing binding characteristics across MCR subtypes
Purity & Quality
- Purity: ≥99% (HPLC verified)
- Peptide content confirmed via Mass Spectrometry
- Certificate of Analysis (CoA) available upon request
Disclaimer
This product is intended for research use only and is not approved for human consumption, therapeutic use, or veterinary application. It is sold strictly for in vitro and laboratory research purposes. This product is not a drug, supplement, or food additive. Researchers must comply with all applicable local, state, and federal regulations governing the use of research peptides.
Frequently Asked Questions
What is PT-141?
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PT-141 (bremelanotide) is a synthetic 7-amino-acid cyclic peptide that selectively activates melanocortin-4 (MC4R) and melanocortin-1 (MC1R) receptors. It is structurally related to MT-2 but with different receptor selectivity. In research it is studied for central nervous system melanocortin signaling. Supplied strictly for Research Use Only.
Is PT-141 the same as bremelanotide?
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Yes. PT-141 and bremelanotide refer to the same molecule. PT-141 was the developmental code; bremelanotide is the international nonproprietary name. Both names map to the identical sequence.
How is PT-141 different from MT-2?
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PT-141 is more selective for MC4R while MT-2 activates a broader range of melanocortin receptors. Research models distinguish the two molecules by the central nervous system pathways activated by MC4R versus the peripheral MC1R-mediated pigmentation pathways.
What is PT-141 used for in research?
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Learn More About PT-141
Research articles and insights related to PT-141
PT-141 Preclinical Behavioral Research: Animal Model Studies
A research review of PT-141 (bremelanotide) preclinical behavioral neuroscience studies covering melanocortin-mediated behavioral endpoints in animal models. For research use only.
June 16, 2026
PT-141 and Melanocortin Receptor Signaling: MC4R Research
A research review of PT-141 melanocortin receptor signaling covering MC3R and MC4R pharmacology, cAMP signaling, and the central melanocortin system in preclinical models. For research use only.
June 16, 2026
PT-141 (Bremelanotide) in Research: Melanocortin Literature Review
A research review of PT-141 (bremelanotide), a melanocortin receptor agonist, covering its proposed mechanism at MC3R and MC4R and the preclinical behavioral neuroscience literature. For research use only.
June 16, 2026
Research Use Only. These products are not supplements, drugs, or intended for human or veterinary use. These products are for laboratory research purposes only. All product information available on this website is for educational purposes only. The products offered on this website are not intended to diagnose, treat, cure, or prevent any disease. Bodily introduction of any kind into humans or animals is strictly forbidden by law. This material is sold for in-vitro research purposes only.
