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CJC-1295 (No DAC)
SKU: CJC1295
$69.99$79.99
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Synthetic GHRH analogue studied for pulsatile growth hormone release research.
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COA Tested
Third-Party Tested
Independent lab verification
COA Available
Certificate of Analysis included
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Research Use Only
For laboratory research purposes
Product Details
CJC-1295 (No DAC) 10mg
For Research Use Only | Not for Human Consumption
Overview
CJC-1295 (No DAC), also known as Modified GRF 1-29 (Mod GRF 1-29), is a synthetic analogue of growth hormone-releasing hormone (GHRH). It is a 29-amino acid peptide that stimulates the pituitary gland to release growth hormone (GH) in a pulsatile manner. The absence of a Drug Affinity Complex (DAC) results in a shorter half-life compared to its DAC counterpart, making it a subject of interest in research focused on natural GH pulse mimicry.
Molecular Profile
| Property | Details |
|---|---|
| Sequence | Tyr-D-Ala-Asp-Ala-Ile-Phe-Thr-Gln-Ser-Tyr-Arg-Lys-Val-Leu-Ala-Gln-Leu-Ser-Ala-Arg-Lys-Leu-Leu-Gln-Asp-Ile-Leu-Ser-Arg-NH₂ |
| Molecular Formula | C₁₄₉H₂₄₆N₄₄O₄₂S |
| Molecular Weight | 3367.9 g/mol |
| CAS Number | 863288-34-0 |
| Form | 10mg lyophilized powder |
| Storage | Lyophilized: -20°C |
| Appearance | White to off-white lyophilized powder |
| Solubility | Soluble in bacteriostatic water or sterile saline |
Mechanism of Action
CJC-1295 (No DAC) binds to GHRH receptors on the anterior pituitary gland, stimulating the release of endogenous growth hormone in a pulsatile fashion. Key characteristics that make it a focus of research include:
- Short half-life of approximately 30 minutes, closely mimicking natural GHRH activity
- Selective binding to GHRH receptors without prolonged receptor occupancy
- Pulsatile GH release patterns relevant to neuroendocrine research
Areas of Research Interest
- Growth hormone secretion studies — examining pulsatile GH release patterns via GHRH receptor activation
- Neuroendocrine research — studying hypothalamic-pituitary axis signaling and feedback mechanisms
- Metabolic pathway research — investigating downstream effects of GH pulse signaling on IGF-1 and related pathways
- Peptide pharmacokinetics — comparing half-life and receptor binding profiles of DAC vs. No DAC variants
- Body composition research — studying GH-related influences on cellular metabolism and tissue signaling
Purity & Quality
- Purity: ≥99% (HPLC verified)
- Peptide content confirmed via Mass Spectrometry
- Certificate of Analysis (CoA) available upon request
Disclaimer
This product is intended for research use only and is not approved for human consumption, therapeutic use, or veterinary application. It is sold strictly for in vitro and laboratory research purposes. This product is not a drug, supplement, or food additive. Researchers must comply with all applicable local, state, and federal regulations governing the use of research peptides.
For research inquiries, bulk pricing, or CoA requests, please contact us directly.
Frequently Asked Questions
What is CJC-1295 No DAC?
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CJC-1295 No DAC is a synthetic 30-amino-acid analog of human growth hormone-releasing hormone (GHRH) based on the GHRH(1-29) sequence with stabilizing modifications, but without the Drug Affinity Complex (DAC) moiety. In research it is studied for GHRH receptor pharmacology and growth hormone pulsatility. Supplied strictly for Research Use Only.
What does No DAC mean?
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DAC stands for Drug Affinity Complex, a maleimidopropionic acid moiety that allows CJC-1295 to bind covalently to circulating albumin and dramatically extend its half-life. The No DAC variant lacks this moiety and has a significantly shorter half-life, producing a more pulsatile profile in research models.
How does CJC-1295 No DAC differ from CJC-1295 with DAC?
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With DAC: extended half-life (days), produces sustained GHRH receptor activation in research models. No DAC: short half-life (~30 min), produces a discrete GH pulse closer to physiological GHRH release patterns. Researchers select the variant based on the pharmacokinetic profile their study requires.
What is CJC-1295 No DAC used for in research?
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Research Use Only. These products are not supplements, drugs, or intended for human or veterinary use. These products are for laboratory research purposes only. All product information available on this website is for educational purposes only. The products offered on this website are not intended to diagnose, treat, cure, or prevent any disease. Bodily introduction of any kind into humans or animals is strictly forbidden by law. This material is sold for in-vitro research purposes only.
